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Disease models

Zebrafish model for narcolepsy

A zebrafish model for narcolepsy could be used to identify new targets or therapeutic leads for the sleep disorder. In zebrafish, selective disruption of hypothalamic hypocretin neurons increased both sleep time during the day and fragmented sleep during the night compared with no disruption. Next steps could include genetic or pharmacological screens to identify targets or compounds that reverse these sleep alterations.

SciBX 5(39); doi:10.1038/scibx.2012.1043
Published online Oct. 4, 2012

Patent and licensing status undisclosed

Elbaz, I. et al. J. Neurosci.; published online Sept. 12, 2012;
Contact: Lior Appelbaum, Bar-Ilan University, Ramat-Gan, Israel