Thursday, October 4, 2012
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Xenopus model for oligodendrocyte myelination
A Xenopus model for
myelination could help identify multiple sclerosis (MS) therapeutics.
Transgenic Xenopus laevis were engineered to express a construct
consisting of a fluorescent reporter linked to the Escherichia coli
1 nitroreductase (ntr).
The construct was then placed under the control of a regulatory sequence
specific to mature oligodendrocytes. In the model, metronidazole,
a generic prodrug that is converted into a cytotoxin by ntr, induced
oligodendrocyte apoptosis and demyelination, resulting in a lower fluorescent
signal than vehicle. Also in the model, the myelinating compound retinoic
acid induced oligodendrocyte proliferation and remyelination,
resulting in a greater fluorescent signal than vehicle. Next steps could
include using the model to test new MS therapeutics.
Published online Oct. 4, 2012
Patent and licensing status
Kaya, F. et al. J.
Neurosci.; published online Sept. 12, 2012;
Contact: Andre Mazabraud, University of South Paris XI, Orsay,
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