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Disease models

Dj-1 (Park7)-deficient mice as models for Parkinson's disease (PD)-associated neurodegeneration

Dj-1-deficient mice could be useful models for PD. The Dj-1-deficient animals were generated by backcrossing Dj-1-null mice with C57BL/6J mice. The resulting Dj-1-deficient mice showed unilateral loss of dopaminergic neurons in the substantia nigra pars compacta region of the brain starting as early as eight weeks that gradually progressed to bilateral degeneration as the animals aged. Whole-exome sequencing identified five coding regions that could be potent modifiers of the observed model phenotype. Next steps include refining the model and using it to identify and evaluate therapeutic targets.

SciBX 5(38); doi:10.1038/scibx.2012.1014
Published online Sept. 27, 2012

Unpatented; model available for licensing

Rousseaux, M.W.C. et al. Proc. Natl. Acad. Sci. USA; published online
Sept. 10, 2012;
Contact: David S. Park, University of Ottawa, Ottawa, Ontario, Canada