Thursday, September 20, 2012
Publication and contact
Epigenetic markers to
predict risk of long-term liver damage
Rat studies suggest
heritable epigenetic modifications induced by liver fibrosis could help
predict long-term liver damage susceptibility in offspring. In male offspring
of rats with a history of chemically induced liver damage, fewer liver
myofibroblasts were generated, liver levels of antifibrotic peroxisome proliferation-activated
increased and levels of profibrotic transforming
growth factor-b (TGFB; TGFb) were
decreased compared with what was seen in rats from parents that underwent
sham injury. In sperm from rats with liver fibrosis, epigenetic modifications
occurred that were absent in sperm from rats without fibrosis. Ongoing
studies include testing whether epigenetic mutations occur in human patients
and predicting risk of long-term liver damage.
SciBX 5(37); doi:10.1038/scibx.2012.992
Published online Sept. 20, 2012
Patent application filed;
available for licensing
Zeybel, M. et al. Nat.
published online Sept. 2, 2012;
Contact: Jelena Mann, Newcastle University, Newcastle upon
Contact: Derek A. Mann,
same affiliation as above
All contents Copyright © 1993-2016 BioCentury Publications, Inc. ALL RIGHTS RESERVED. All use of this Web Site and its contents is governed by the BioCentury User Agreement
. The contents of this Web Site are protected under U.S. and foreign copyright and intellectual property laws, and no part of this Web Site or its contents may be photocopied, reproduced or retransmitted in any form without the written consent of BioCentury, which may be requested from Reprints/Permissions
. BioCentury®; The Bernstein Report on BioBusiness™; The BioCentury 100™; The Clear Route to ROI™; Because Real Intelligence is Hard to Find™; BCIQ™; and BioPharma's Knowledge Center™; are trademarks of BioCentury Publications, Inc., P.O. Box 1246, San Carlos, CA 94070. SciBX® and SciBX: Science-Business eXchange® are trademarks of Nature America, Inc. that are jointly used by BioCentury Publications, Inc. and Nature America, Inc.
Thanks for purchasing this article.
Please bookmark this url for future reference.
We have also sent you a confirming e-mail with a receipt and this same url for your
close [ X ]