Thursday, September 20, 2012
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Assays & screens
arrays for mapping antibody-histone interactions
A silicon-based peptide
array for mapping the interactions of antibodies with differentially modified
histones could be used to identify patients who will respond to therapy. An
array was constructed that contained all possible peptides found in the N-terminal
domain of histone
H2B ranging from 1 to 21 amino acids in length and included all
combinations of these peptides in unmodified, acetylated or methylated forms.
Autoantibodies in the sera of patients with severe systemic lupus erythematosus
(SLE) showed greater reactivity with distinct epitopes on the arrays than
autoantibodies from patients with low disease severity. Next steps include
testing whether autoantibody specificity can be used to predict response to
therapy in patients with SLE and other autoimmune diseases.
Published online Sept. 20, 2012
Unpatented; available for
licensing or partnering
Price, J.V. et al. Nat.
published online Aug. 19, 2012;
Contact: Jordan V. Price,
Stanford University School of Medicine, Stanford, Calif.
Contact: Paul J. Utz, same affiliation as above
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