Thursday, September 13, 2012
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Assays & screens
Human blood metabolite-based
A human blood metabolite-based
timetable could help estimate internal body time with just two blood samples.
Delivering drugs based on internal body time is associated with improved
therapeutic efficacy and reduced side effects, but measuring internal body
time requires constant sampling of metabolite levels for more than 24 hours.
Blood samples from human subjects were taken every 2 hours over 1.5 days and
used to create a reference internal body timetable based on metabolite levels
at various time points. In paired human blood samples taken 12 hours apart,
the resulting reference metabolite timetable was able to predict internal
body time to within 3 hours. Next steps include testing the timetable in
additional subjects and developing a strategy to only require a single blood
SciBX 5(36); doi:10.1038/scibx.2012.963
Published online Sept. 13, 2012
Patent pending; available
T. et al. Proc. Natl. Acad. Sci. USA; published online Aug. 27,
Contact: Hiroki R. Ueda, RIKEN Quantitative Biology Center, Hyogo, Japan
Contact: Tomoyoshi Soga, Keio University, Yamagata, Japan
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