Thursday, September 13, 2012
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Assays & screens
Class A b-lactamase
detection of Mycobacterium
Fluorescent probes specific
tuberculosis blaC could be useful
for detecting M.
tuberculosis in clinical samples.
Chemically modified cephalosporins that release a
fluorophore when bound to blaC were synthesized. In vitro, the probes emitted a fluorescence signal and
showed 1,000-fold greater selectivity for blaC over a closely related class A
b-lactamase produced by other bacterial strains. In
unprocessed patient sputum samples, the lead probe detected M. tuberculosis within 10 minutes even when fewer than 10
colony-forming units of bacilli were present. Global BioDiagnostics Corp. is conducting
a proof-of-concept study on the probes and has begun development of a
diagnostic to detect M. tuberculosis (see Probing for a point-of-care TB test, page 8).
SciBX 5(36); doi:10.1038/scibx.2012.962
Published online Sept. 13, 2012
Multiple patents pending;
licensed to Global BioDiagnostics
Xie, H. et al. Nat. Chem.; published online Sept. 2, 2012;
Contact: Jianghong Rao, Stanford University, Stanford,
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