Thursday, September 6, 2012
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T cell migration across the
blood brain barrier (BBB)
The mechanism of T cell
migration across the BBB could help identify new therapeutic targets for
multiple sclerosis (MS) and other CNS-related autoimmune diseases. In a rat
model of experimental autoimmune encephalitis (EAE), cell tracing studies
showed that reactive T cells were unable to efficiently cross the BBB unless
they first migrated to the lung, where their gene expression profiles were
reprogrammed. The reprogramming downregulated expression of genes related to
T cell activation and upregulated expression of genes related to cellular
locomotion, adhesion and chemokine signaling. Next steps include determining
whether T cells in patients with MS show a similar migratory pattern and
identifying new therapeutic targets based on the changes in gene expression
SciBX 5(35); doi:10.1038/scibx.2012.940
Published online Sept. 6, 2012
status not applicable
Odoardi, F. et al.
Nature; published online Aug. 22, 2012;
Contact: Alexander Flügel, Hertie Foundation and University
Medical Center Goettingen, Goettingen, Germany
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