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Anandamide-small interfering RNA conjugates for targeting neuronal and immune cells

Anandamide-siRNA conjugates that silence gene expression in neuronal and immune cells could be useful for treating immunological and neurological diseases. The conjugates were generated by linking alkyne-modified RNA with 3ʹ-anandamide and produced at high yield and purity. In a rat basophilic leukemia cell line that models neuronal cells and astrocytes, the anandamide-siRNA conjugates decreased expression of a targeted gene compared with unmodified RNA duplexes and anandamide-modified scrambled siRNA. Next steps could include determining the tissue distribution of the anandamide-siRNA conjugates in animal models.

SciBX 5(34); doi:10.1038/scibx.2012.912
Published online Aug. 30, 2012

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Willibald, J. et al. J. Am. Chem. Soc.; published online July 19, 2012;
Contact: Thomas Carell, Ludwig Maximilian University of Munich, Munich, Germany