Thursday, August 23, 2012
Publication and contact
Expression of herpes
simplex virus (HSV) thymidine kinase in human embryonic
stem cells (hESCs) as a strategy to prevent teratoma formation
mouse studies identified a strategy to prevent teratoma formation in
hESC-derived cellular therapies. hESCs were engineered to express HSV
thymidine kinase, which is not expressed by differentiated cells or healthy
human cells. In culture, the thymidine kinase inhibitor Zirgan
induced death of engineered hESCs but not differentiated cells derived from
the engineered hESCs. In mice transplanted with the engineered hESCs or
partially differentiated engineered hESCs, ganciclovir prevented teratoma
formation whereas saline did not. Next steps include testing the strategy in
Thea S.A. markets Zirgan to treat HSV
Published online Aug. 23, 2012
available for licensing
Rong, Z. et al. J. Biol.
published online Aug. 4,
Contact: Yang Xu, University of California, San Diego, La
All contents Copyright © 1993-2015 BioCentury Publications, Inc. ALL RIGHTS RESERVED. All use of this Web Site and its contents is governed by the BioCentury User Agreement
. The contents of this Web Site are protected under U.S. and foreign copyright and intellectual property laws, and no part of this Web Site or its contents may be photocopied, reproduced or retransmitted in any form without the written consent of BioCentury, which may be requested from Reprints/Permissions
. BioCentury®; The Bernstein Report on BioBusiness™; The BioCentury 100™; The Clear Route to ROI™; Because Real Intelligence is Hard to Find™; BCIQ™; and BioPharma's Knowledge Center™; are trademarks of BioCentury Publications, Inc., P.O. Box 1246, San Carlos, CA 94070. SciBX® and SciBX: Science-Business eXchange® are trademarks of Nature America, Inc. that are jointly used by BioCentury Publications, Inc. and Nature America, Inc.
Thanks for purchasing this article.
Please bookmark this url for future reference.
We have also sent you a confirming e-mail with a receipt and this same url for your
close [ X ]