Thursday, August 23, 2012
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Expression of herpes
simplex virus (HSV) thymidine kinase in human embryonic
stem cells (hESCs) as a strategy to prevent teratoma formation
mouse studies identified a strategy to prevent teratoma formation in
hESC-derived cellular therapies. hESCs were engineered to express HSV
thymidine kinase, which is not expressed by differentiated cells or healthy
human cells. In culture, the thymidine kinase inhibitor Zirgan
induced death of engineered hESCs but not differentiated cells derived from
the engineered hESCs. In mice transplanted with the engineered hESCs or
partially differentiated engineered hESCs, ganciclovir prevented teratoma
formation whereas saline did not. Next steps include testing the strategy in
Thea S.A. markets Zirgan to treat HSV
Published online Aug. 23, 2012
available for licensing
Rong, Z. et al. J. Biol.
published online Aug. 4,
Contact: Yang Xu, University of California, San Diego, La
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