Thursday, August 23, 2012
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Genetic mouse model of
multiple myeloma (MM)
A genetic mouse model of MM
could help identify new compounds to treat the disease. Mice were engineered
to express the MM-associated oncogene v-maf
musculoaponeurotic fibrosarcoma oncogene homolog B (Mafb)
in hematopoietic stem and progenitor cells. In these mice, hematopoietic
cells terminally differentiated into B cells expressing the oncogene, and the
animals developed features that recapitulated MM in humans, including lytic
bone lesions and plasma cell tumors. Next steps include using the model to
test therapeutic candidates for MM.
Published online Aug. 23, 2012
Patented; available for
Vicente-Dueñas, C. et al. EMBO J.; published online Aug.
Contact: Isidro Sánchez-García,
Spanish National Research
Council and University of Salamanca, Salamanca, Spain
Contact: César Cobaleda, Spanish National Research Council
and Autonomous University of Madrid, Madrid, Spain
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