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Disease models

Genetic mouse model of multiple myeloma (MM)

A genetic mouse model of MM could help identify new compounds to treat the disease. Mice were engineered to express the MM-associated oncogene v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (Mafb) in hematopoietic stem and progenitor cells. In these mice, hematopoietic cells terminally differentiated into B cells expressing the oncogene, and the animals developed features that recapitulated MM in humans, including lytic bone lesions and plasma cell tumors. Next steps include using the model to test therapeutic candidates for MM.

SciBX 5(32); doi:10.1038/scibx.2012.880
Published online Aug. 23, 2012

Patented; available for licensing

Vicente-Dueñas, C. et al. EMBO J.; published online Aug. 17, 2012;
Contact: Isidro Sánchez-García,

Spanish National Research Council and University of Salamanca, Salamanca, Spain
Contact: César Cobaleda, Spanish National Research Council and Autonomous University of Madrid, Madrid, Spain