Thursday, August 23, 2012
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Assays & screens
Assay measuring impact of
secreted proteins on kinase inhibitor sensitivity in human tumor-derived cell
An assay measuring the
impact of secreted proteins on kinase inhibitor sensitivity in human tumor-derived
cell lines could guide the development of combination therapies to prevent
drug resistance. A cell-based assay screened the potential of 3,482 secreted
proteins to activate alternative kinase pathways and cause resistance to
kinase inhibitors in tumor cells. A number of secreted proteins induced
resistance, with ligands of epidermal
growth factor receptor 1 (EGFR1;
growth factor receptor (FGFR)
proto-oncogene (MET; HGFR)
families showing a broad ability to compensate for inhibition of the original
targeted kinase. Next steps could include analyzing the effects of secreted
proteins in additional kinase-activated, human tumor-derived cell lines.
Published online Aug. 23, 2012
Patent and licensing status
Harbinski, F. et al.
Cancer Discov.; published online Aug. 10, 2012;
Contact: Ralph Tiedt, Novartis Institutes for BioMedical
Research, Basel, Switzerland
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