Thursday, August 16, 2012
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Genetic lineage markers for
identifying skin cancer stem cells
studies suggest genetic lineage markers could be useful for identifying
compounds that target skin cancer stem cells. A standard mouse model of
chemical-induced skin cancer was engineered to express yellow fluorescent
protein (YFP) in skin papillomas. Tracking the YFP signal over time revealed
two subpopulations of tumor cells in the papilloma, one with stem cell-like
features and the other with proliferative features. Further quantitative
analysis of the papillomas led to a model of tumor growth that suggests a
minority population of stem cell-like tumor cells gives rise to a pool of
proliferative progenitor cells that lead to terminally differentiated tumor
cells. Next steps include using the lineage-tracing assay to identify
cellular pathways that contribute to dysregulation of cancer stem cells (see Tracing cancer stem
cells, page 1).
SciBX 5(32); doi:10.1038/scibx.2012.856
Published online Aug. 16, 2012
status not applicable
Driessens, G. et al. Nature; published online Aug. 1, 2012;
Contact: Benjamin Simons, University of Cambridge,
Contact: Cédric Blanpain, Free
University of Brussels, Brussels, Belgium
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