Thursday, August 16, 2012
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Genetic lineage markers for
identifying intestinal cancer stem cells
Mouse studies suggest
genetic lineage markers may be useful for identifying compounds that target
intestinal cancer stem cells. A mouse model of adenomatous polyposis coli (Apc)-mutant intestinal adenoma was crossed with mice
expressing R26-Confetti, a gene that marks leucine-rich repeat-containing G protein-coupled
receptor 5 (Lgr5; Gpr49) in one of four
different fluorescent colors. In the resulting mouse strain, the
color-indicating Lgr5, an intestinal crypt stem cell marker, was enriched in
a subpopulation of adenoma cells, suggesting the latter were cancer stem
cells. Fluorescent tracking of the
Lgr5-enriched adenoma cells confirmed they were multipotent and gave rise to
the other cell types in the adenoma. Next steps could include isolating and
further characterizing the stem cell properties of the Lgr5-enriched adenoma
cells (see Tracing cancer stem cells, page 1).
SciBX 5(32); doi:10.1038/scibx.2012.855
Published online Aug. 16, 2012
Patent and licensing status
Schepers, A.G. et al. Science; published online Aug. 1, 2012;
Contact: Hans Clevers, Hubrecht Institute, Utrecht, the
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