Thursday, August 16, 2012
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Mouse models of human CC chemokine receptor 9 (CCR9; CDw199)-expressing
Mouse models based on
CCR9-expressing human colorectal cancer cell lines could help identify new
therapies to treat the disease. In colorectal cancer tumors from patients,
CCR9 levels were upregulated in primary tumors and downregulated in
metastatic tumors. In mice, cell lines derived from the
CCR9-expressing primary colorectal cancer tumors produced a larger number of
gastrointestinal tumors than cell lines derived from the metastatic tumors.
In mice receiving the CCR9-expressing cells, small hairpin RNA against CCR9 decreased tumor formation in the gastrointestinal
tract but also increased tumor formation outside of it compared with
scrambled control shRNA. Ongoing work includes using multiple CCR9-expressing
colorectal cancer cell lines in xenograft mouse models to identify inhibitors
of colorectal cancer metastasis.
SciBX 5(32); doi:10.1038/scibx.2012.852
Published online Aug. 16, 2012
Patent application filed
covering the CCR9-expressing colorectal cancer cell lines; available for
Chen, H.J. et al. J. Clin. Invest.; published online Aug. 6, 2012;
Contact: Steven Lipkin, Weill Cornell Medical College, New
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