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Disease models

Induced pluripotent stem (iPS) cell-derived neurons from patients with familial Parkinson's disease (PD)

iPS cell-derived neurons from patients with PD may help characterize disease phenotypes and aid in the identification of therapeutics that correct the phenotypes. iPS cell-derived neurons from patients with leucine-rich repeat kinase 2 (LRRK2) and PTEN induced putative kinase 1 (PINK1) mutations were more sensitive to PD-associated chemical toxins and stressors than neurons derived from healthy controls. Neurons from patients with LRRK2 mutations had greater mitochondrial mobility than neurons from patients with PINK1 mutations or healthy controls. Next steps include generating iPS cell-derived neurons from other patients with familial PD.

SciBX 5(32); doi:10.1038/scibx.2012.851
Published online Aug. 16, 2012

Patent application filed; available for licensing

Cooper, O. et al. Sci. Transl. Med.; published online July 4, 2012;
Contact: Ole Isacson, Harvard Medical School, Boston, Mass.