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Disease models

Guinea pig models for assessing safety of human embryonic stem cell (hESC)-derived cardiomyocyte transplants

Guinea pigs could help assess the safety and efficacy of hESC-derived cardiomyocyte transplants. In guinea pig models of cardiac injury,
hESC-derived cardiomyocyte grafts integrated with host cardiac tissue and beat synchronously with host cardiomyocytes. The cardiomyocyte grafts also decreased left ventricular dilation and deterioration and the incidence of ventricular tachycardia compared with noncardiomyocyte grafts. Ongoing work includes testing methods for improving the performance of hESC-derived cardiomyocyte transplants in the guinea pig models.

SciBX 5(32); doi:10.1038/scibx.2012.850
Published online Aug. 16, 2012

Unpatented; available for partnering

Shiba, Y. et al. Nature; published online Aug. 5, 2012;
Contact: Michael A. Laflamme, University of Washington, Seattle, Wash.
Contact: Charles E. Murry, same affiliation as above