Skip to main content
Home > BC Innovations > Targets & Mechanisms

Chronological Index of : Targets & Mechanisms

 Current Issue
  • Figure: Ketamine mimics

    Dissociating ketamine Targets & Mechanisms Ketamine mimics The anesthetic ketamine is an NMDA receptor antagonist known to have antidepressant activity, but it also causes severe psychedelic side effects. In a …

    Published on 5/26/2016
  • Table: BioCentury Product Profile

    Dissociating ketamine Targets & Mechanisms BioCentury Product Profile BIOCENTURY PRODUCT PROFILE INNOVATION STAGE Product (2R,6R)-hydroxynorketamine Concept A ketamine metabolite that recapitulates the drug's …

    Published on 5/26/2016
  • Figure: NET inflammation in flu

    Another shot at the flu Targets & Mechanisms NET inflammation in flu A new study in Science from Yale University researchers suggests inhibiting caspase-1 and other caspases could help prevent the excessive …

    Published on 5/12/2016
  • Table: Biocentury Product Profile

    Another shot at the flu Targets & Mechanisms Biocentury Product Profile BIOCENTURY PRODUCT PROFILE INNOVATION STAGE Product Inhibitors of caspase-1, caspase-4 and caspase-5 Concept Blocking caspase-induced …

    Published on 5/12/2016
  • Another shot at the flu

    Targeting caspases may prevent flu-associated death in the elderly

    Human ex vivo studies and genetic analysis of a mouse model of flu in older humans have identified three caspases as new targets for treating flu in the elderly.

    Published on 5/12/2016
  • Figure: Taking down SAMMSON

    Better call Delilah Targets & Mechanisms Taking down SAMMSON In a study published in Nature, researchers from Catholic University Leuven, Flanders Institute for Biotechnology (VIB) and Ghent University showed the …

    Published on 5/5/2016
  • Table: Biocentury Product Profile

    Better call Delilah Targets & Mechanisms Biocentury Product Profile BIOCENTURY PRODUCT PROFILE INNOVATION STAGE Product Long non-coding RNA (lncRNA) SAMMSON as marker of malignant melanoma Antisense …

    Published on 5/5/2016
  • Better call Delilah

    Cutting SAMMSON strands to weaken melanoma

    SAMMSON, a newly identified lncRNA, is up-regulated in a wide range of melanomas, irrespective of genetic background, and could lead to new antisense therapeutics.

    Published on 5/5/2016
  • Structural SERT-ainty

    SERT crystallography defines two SSRI binding sites

    The crystal structure of the serotonin transporter has revealed a primary ligand-binding site and an allosteric site that offer opportunities for new drug design.

    Published on 4/21/2016
  • Figure: An SSRI in-SERTs twice

    Structural SERT-ainty Targets & Mechanisms An SSRI in-SERTs twice In a study published in Nature, a team from the Vollum Institute at Oregon Health & Science University (OHSU) has finally solved the crystal …

    Published on 4/21/2016
  • Box: Questioning UCP1

    Brown fat heats up Targets & Mechanisms Questioning UCP1 While there is evidence that manipulating targets such as FGF21, USF1 and SLIT2 promote both metabolic benefits and brown fat activity, it is still not clear…

    Published on 3/10/2016
  • Figure: Feel the burn

    Brown fat heats up Targets & Mechanisms Feel the burn Three studies have identified new molecular targets to treat obesity and metabolic diseases by enhancing thermogenesis - a process in which brown or beige …

    Published on 3/10/2016
  • Table: BioCentury Product Profile

    Brown fat heats up Targets & Mechanisms BioCentury Product Profile BioCentury Product Profile INNOVATION STAGE Product A small molecule inhibitor of the protease FAP C-terminal fragment of SLIT2 Concept A …

    Published on 3/10/2016
  • Table: Brown and beige fat targets

    Brown fat heats up Targets & Mechanisms Brown and beige fat targets Selected targets for modifying beige or brown fat to treat obesity and metabolic diseases, identified in the Distillery section of BioCentury …

    Published on 3/10/2016
  • Table: Brown and beige fat targets

    Brown fat heats up Targets & Mechanisms Brown and beige fat targets Selected targets for modifying beige or brown fat to treat obesity and metabolic diseases, identified in the Distillery section of BioCentury …

    Published on 3/10/2016
  • Brown fat heats up

    Casting a wide net for brown and beige fat targets in metabolic diseases

    The list of obesity targets in brown and beige fat is extending well beyond FGF21, with three studies showing new possibilities since the start of the year.

    Published on 3/10/2016
  • Targeting TMP

    New ways to target bacterial DNA synthesis

    Mechanistic insights into the unique chemistry of a bacteria-specific thymidylate synthesis pathway could lead to better antibiotics.

    Published on 3/3/2016
  • Figure: AKTing on SHANK3

    Rescue mission Targets & Mechanisms AKTing on SHANK3 A team at Novartis Institutes for BioMedical Research (NIBR) has identified three new autism targets (purple) and is designing small molecules against the …

    Published on 3/3/2016
  • Table: BioCentury Product Profile

    Rescue mission BioCentury Product Profile INNOVATION STAGE Product A small molecule inhibitor of CLK-2 or PPP2CA, or activator of AKT, that crosses the blood-brain barrier Concept A treatment for autism that …

    Published on 3/3/2016
  • Rescue mission

    Rescuing synapses in SHANK3 mice

    Two studies on the autism target SHANK3 suggest some symptoms can be reversed even after childhood and present a new small molecule strategy.

    Published on 3/3/2016
  • Borrowing for Zika

    Additional strategies to combat Zika spread

    While companies and agencies chase traditional routes to a Zika vaccine, some groups are borrowing strategies from Ebola, dengue and malaria for alternative ways to stop the disease.

    Published on 2/25/2016
  • Table: Finding funds for Zika

    Borrowing for Zika Targets & Mechanisms Finding funds for Zika Since January 2016, at least seven public funding institutions or foundations have announced grants or called for initiatives for research into the …

    Published on 2/25/2016
  • Figure: One fox two fox

    Staking out foxholes: Figure: One fox two fox Staking out foxholes Targets & Mechanisms One fox, two fox Researchers from Memorial Sloan Kettering Cancer Center have shown the transcription factor FOXO1 keeps Tregs …

    Published on 2/18/2016
  • Figure: Surveillance state

    Staking out foxholes: Figure: Surveillance state Staking out foxholes Targets & Mechanisms Surveillance state Researchers from Memorial Sloan Kettering Cancer Center have identified a population of immune cells that…

    Published on 2/18/2016
  • Staking out foxholes

    Two MSKCC studies, two potential ways to improve antitumor immunity

    A pair of MSKCC studies unravels new biology for dialing down immune suppression and dialing up immunosurveillance.

    Published on 2/18/2016

< Previous   1  2  3  4  5  6  Next >

About BioCentury

Decision-shaping business intelligence for the global biotech and pharma industry since 1993