The long-standing mystery of how adipsin
regulates metabolism has been solved by a Harvard-led team that has shown the
enzyme can increase insulin secretion by generating the
peptide complement 3a.1 Its
therapeutic potential may hinge on showing that the effect persists with
chronic dosing and does not trigger inflammation or other unwanted side
new connection between adipose tissue and islet function provides a valuable
mechanistic link, but the therapeutic potential of adipsin in obesity and
diabetes still requires longer-term proof of concept.
T. SciBX 7(30);
doi:10.1038/scibx.2014.883 Published online Aug. 7, 2014
J.C. et al. Cell; published online June 23, 2014;
doi:10.1016/j.cell.2014.06.005 Contact: Bruce M. Spiegelman, Harvard Medical School, Boston, Mass. e-mail: email@example.com
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Australian National University Medical School, Canberra, Australian Capital Territory, Australia
Canberra, Australian Capital Territory, Australia
Dana-Farber Cancer Institute, Boston, Mass.
Ember Therapeutics Inc., Boston, Mass.
South San Francisco, Calif.
Harvard Medical School, Boston, Mass.
Karolinska Institute, Stockholm, Sweden
Novo Nordisk A/S (CSE:NVO;
NYSE:NVO), Bagsvaerd, Denmark
OTCQX:RHHBY), Basel, Switzerland
University of Ancona, Ancona, Italy
University of Leipzig, Leipzig, Germany
University of Michigan Medical School, Ann Arbor, Mich.
The University of Tokyo, Tokyo, Japan