Despite the clear rationale for using hedgehog
inhibitors in pancreatic cancer-they deplete the stroma to improve chemotherapy
delivery-clinical results have been disappointing. New data suggest that the
large amounts of stroma surrounding some pancreatic cancers might actually have
pair of papers in Cancer Cell could explain the weak showing for SMO
inhibitors in pancreatic cancer.
said that his group is now working to elucidate the role of various stromal
cell populations in PDAC.
K.-J. SciBX 7(23); doi:10.1038/scibx.2014.665
Published online June 12, 2014
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Contact: Kenneth P. Olive, Columbia University Medical Center, New York,
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Cancer Cell; published online May 22, 2014; doi:10.1016/j.ccr.2014.04.005
Contact: Raghu Kalluri, The University of Texas MD Anderson Cancer Center,
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AND INSTITUTIONS MENTIONED
Bristol-Myers Squibb Co. (NYSE:BMY), New York, N.Y.
Cancer Research UK, London, U.K.
Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
Columbia University Medical Center, New York, N.Y.
South San Francisco, Calif.
Halozyme Therapeutics Inc. (NASDAQ:HALO), San Diego, Calif.
Infinity Pharmaceuticals Inc. (NASDAQ:INFI), Cambridge, Mass.
Lustgarten Foundation, New York, N.Y.
(NYSE:NVS; SIX:NOVN), Basel, Switzerland
(SIX:ROG; OTCQX:RHHBY), Basel, Switzerland
Perelman School of Medicine at the University of
Technical University Munich, Munich, Germany
University of California, Davis Comprehensive Cancer Center, Davis, Calif.
The University of Texas MD Anderson Cancer Center, Houston, Texas