A team from Weill Cornell Medical College
has found a unifying feature of triple-negative breast cancers-overactivation
of the transcription factor X-box
binding protein 1-that could open the door to new therapies
for this notoriously hard-to-treat disease.1 Although blocking
expression of this target, which is involved in the unfolded protein response,
decreases tumor formation and relapse in mice, more druggable targets upstream
of it might be better suited for further development.
unfolded protein response is part of the cellular adaptive response to stress.
In normal cells the response is activated when improperly folded proteins
accumulate in the endoplasmic reticulum following exposure to stimuli such as
told SciBX that the next step is to extend the studies' validation using
multiple preclinical models with patient-derived xenografts representing major
triple-negative breast cancer subtypes and with genetically engineered mouse
models bearing mutations seen in human triple-negative breast cancers.
Boettner, B. SciBX
Published online April 17, 2014
1. Chen, X. et al. Nature; published online March 23, 2014; doi:10.1038/nature13119
Contact: Laurie H. Glimcher, Weill Cornell Medical
College, New York, N.Y.
2. Carey, L. et al. Nat. Rev. Clin. Oncol. 7, 683-692 (2010)
3. Wen, X.Y. et al. Int. J. Oncol. 15,
4. Moenner, M. et al. Cancer Res. 67,
5. The Cancer Genome Atlas Network. Nature 490, 61-70
6. Schwab, L.P. et al. Breast Cancer Res. 14, R6 (2012)
7. Conley, S.J. et al. Proc. Natl. Acad. Sci. USA 109, 2784-2789 (2012)
AND INSTITUTIONS MENTIONED
BC Cancer Agency,
Vancouver, British Columbia, Canada
Boston Children's Hospital, Boston, Mass.
Brigham and Women's Hospital, Boston, Mass.
Dana-Farber Cancer Institute, Boston, Mass.
Harvard School of Public Health, Boston, Mass.
Institut National de la Santé et de la Recherche Médicale, Bordeaux, France
(NASDAQ:MNKD), Valencia, Calif.
Palo Alto, Calif.
Sichuan Agricultural University, Ya'an, China
University of Bordeaux Segalen, Bordeaux, France
University of California, Los Angeles, Calif.
The University of North Carolina at Chapel Hill, Chapel Hill, N.C.
Weill Cornell Medical College, New York, N.Y.