Thursday, February 20, 2014
A Cornell University team has shown
how knocking out checkpoint kinase 2 can
preserve fertility in mice.1 The results suggest that companies have
an opportunity with this kinase, which is less pursued than the well-trodden
cancer target checkpoint kinase 1, to
prevent chemotherapy- and radiotherapy-induced premature menopause and
The team's next steps include sequencing
the genomes of the pups to check for potential mutations and other defects and
identifying the mechanism responsible for repairing oocyte DSB damage.
Baas, T. SciBX 7(7);
Published online Feb. 20, 2014
E. et al. Science; published online Jan. 31, 2014;
Contact: John C. Schimenti, Cornell University, Ithaca, N.Y.
2. Hirao, A. et
al. Mol. Cell Biol. 22, 6521-6532 (2002)
3. Wang, X.Q. et al. J.
Cell. Physiol. 208, 613-619 (2006)
4. Anderson, V.E. et
al. Cancer Res. 71, 463-472 (2011)
AND INSTITUTIONS MENTIONED
AstraZeneca plc (LSE:AZN; NYSE:AZN), London,
Cancer Research UK, London, U.K.
Cornell University, Ithaca, N.Y.
The Institute of Cancer Research, London, U.K.
(Xetra:MRK), Darmstadt, Germany
Sbarro Health Research Organization, Philadelphia, Pa.