BioCentury
ARTICLE | Targets & Mechanisms

Getting to the root of periodontitis

November 21, 2013 8:00 AM UTC

Current periodontitis therapies do not target the underlying immune response that drives the disease. A team from the U.S. and Brazil is looking to change that and has shown that microparticles loaded with chemokine CC motif ligand 22 recruited Treg cells to the gingiva and slowed periodontitis progression in mice and dogs.1

Future studies will need to determine whether the microparticle-based therapy can help treat patients with more advanced disease who already have substantial loss of tooth-supporting alveolar bone...