Thursday, September 26, 2013
Researchers at The Johns Hopkins University School of Medicine
have proposed that mental retardation caused by Down syndrome could be prevented
or mitigated after birth with a small molecule activator of the sonic
hedgehog homolog pathway.1 The group's mouse data
show improvements in brain development, learning and memory. However, the
narrow therapeutic window and the long gap in time between treatment and
evaluation of cognitive endpoints in patients will pose significant
L. SciBX 6(37);
doi:10.1038/scibx.2013.1017 Published online Sept. 26, 2013
1. Das, I. et al. Sci.
Transl. Med.; published online Sept. 4, 2013; doi:10.1126/scitranslmed.3005983
Contact: Roger H. Reeves, The Johns Hopkins University School of
Medicine, Baltimore, Md. e-mail: email@example.com
2. Roper, R.J. et al.
Proc. Natl. Acad. Sci. USA 103, 1452-1456 (2006)
3. Heine, V.M. et al.
Sci. Transl. Med. 3, 105ra104 (2011)
N. et al. J. Neurosci. 33, 15408-15413 (2013)
AND INSTITUTIONS MENTIONED
Curis Inc. (NASDAQ:CRIS), Lexington, Mass.
Genentech Inc., South San Francisco, Calif.
Howard Hughes Medical Institute, Chevy Chase, Md.
Johns Hopkins University School of Medicine, Baltimore, Md.
Netherlands Institute for Neuroscience, Amsterdam, the Netherlands
(SIX:ROG; OTCQX:RHHBY), Basel, Switzerland
University of California, San Francisco, Calif.