Thursday, July 18, 2013
Figure 1. Hitting
ceramide for depression.
Gulbins et al. have evidence that blocking the production of ceramide, a
phospholipid signaling molecule, has antidepressive effects.
the membrane-associated phospholipid sphingomyelin [a] is cleaved by sphingomyelin phosphodiesterase 1
acid lysosomal (SMPD1; ASM) [b] to
yield ceramide [c]. Gulbins et al. showed that in cell culture
and mice, accumulation of ceramide correlated with depressive behavior and
reduced neuronal growth and survival [d].
also showed that two known antidepressants-fluoxetine and amitriptyline-lowered
ceramide levels and decreased activity of SMPD1 compared with no treatment.
Fendiline, a nonselective calcium channel blocker, also reduced SMPD1 activity
and normalized depression-like behavior.