Figure 1. Dopamine stressed out over glucocorticoids. Environmental triggers induce the release of plasma glucocorticoids [a], which influence dopamine signaling in the brain by either directly altering dopamine neurotransmission between cells [b] or indirectly altering the epigenetic properties of genes involved in dopamine biosynthesis [c]. The resulting alterations lead to behavioral aberrations indicative of anxiety and depression [d].