Thursday, November 29, 2012
Model of triptolide release from minnelide. Minnelide consists of a phosphonooxymethyl prodrug
group that increases the compound's solubility in water.
which are present in blood and many bodily tissues, cleave the phosphate group
from minnelide to yield an unstable O-hydroxymethyl intermediate. This
intermediate then degrades into formaldehyde and the anticancer compound