Thursday, September 6, 2012
Blocking amyloid growth.
Kroth et al. have designed small molecules to block the formation and
growth of amyloid, an aberrant protein thought to cause Alzheimer's disease
In AD, amyloid precursor protein
proteolytically cleaved to produce the b-amyloid (Ab)
fragment [a]. This fragment is thought to spontaneously fold into an aberrant
structural form [b] prone to clumping together in other misfolded
molecules of its type [c]. Over time, this oligomeric aggregate grows
into a large, structurally repetitive amyloid fibril [d].
AC Immune S.A.'s
small molecules bind to the ends of amyloid oligomers and fibrils, blocking
their growth [e] and thus preventing AD progression [f].