Thursday, August 23, 2012
Antibodies can target the head or stalk of the hemagglutinin protein to provide
different mechanisms of action.
(I) Anti-influenza A virus hemagglutinin
(HA) antibodies that bind to the HA globular head inhibit virus binding to host
cells through the sialic acid receptor, thus preventing virus entry.
Anti-HA antibodies that bind to the HA stalk region prevent the HA
conformational changes needed to allow fusion of the viral envelop with the
host membrane, impeding progression of the virus life cycle.