Thursday, July 19, 2012
Researchers in New York have identified G
receptor 17 as a target on agouti
related protein-expressing neurons, which are known to
regulate multiple factors related to obesity.1 The findings open up
a new molecular signaling pathway to mine for targets to control obesity-earlier
attempts to inhibit these neurons via insulin and leptin signaling pathways have had little success.
Lou, K.-J. SciBX 5(28); doi:10.1038/scibx.2012.720 Published online July
1. Ren, H. et al. Cell;
published online June 8, 2012; doi:10.1016/j.cell.2012.04.032 Contact:
Domenico Accili, Columbia University, New York, N.Y. e-mail: firstname.lastname@example.org
2. Könner, A.C. et al.
Cell Metab. 5, 438-449 (2007)
3. van de Wall, E. et
al. Endocrinology 149, 1773-1785 (2008)
4. Wang, J. et al.
Diabetes 50, 2786-2791 (2001)
5. Kim, M.-S. et al.
Nat. Neurosci. 9, 901-906 (2006)
6. Kitamura, T. et al.
Nat. Med. 12, 534-540 (2006)
7. Ciana, P. et al.
EMBO J. 25, 4615-4627 (2006)
AND INSTITUTIONS MENTIONED
Albert Einstein College of Medicine of Yeshiva University, New York, N.Y.
AstraZeneca plc (LSE:AZN; NYSE:AZN), London, U.K.
Columbia Technology Ventures, New York, N.Y.
Columbia University, New York, N.Y.
Max Planck Institute for Neurological Research, Cologne, Germany
The Medicines Co. (NASDAQ:MDCO), Parsippany, N.J.
University of Cincinnati, Cincinnati, Ohio
Yale School of Medicine, New Haven, Conn.