Thursday, May 24, 2012
A Harvard Medical School-led team
has shown that a soluble form of VEGF
receptor 1 causes about one-third of peripartum
cardiomyopathy cases-those associated with preeclampsia.1 Ongoing
studies are seeking to identify small molecule inhibitors of the protein and
determine whether the mechanism also underlies the other two-thirds of cases.
Flt to be
Haas, M.J. SciBX 5(21);
Published online May 24, 2012
1. Patten, I.S. et al. Nature; published online May 9, 2012;
Contact: Zoltan Arany, Harvard Medical School, Boston, Mass.
Contact: Denise Hilfiker-Kleiner, Hannover Medical School,
2. Levine, R.J. et al. N. Engl. J.
Med. 350, 672-683 (2004)
3. Thadhani, R. et al. Circulation 124, 940-950 (2011)
4. Rana, S. et al. Circulation 125, 911-919 (2012)
AND INSTITUTIONS MENTIONED
Beth Israel Deaconess Medical Center, Boston, Mass.
GlaxoSmithKline plc (LSE:GSK; NYSE:GSK), London, U.K.
Hannover Medical School, Hannover, Germany
Harvard Medical School, Boston, Mass.
Howard Hughes Medical Institute, Chevy Chase, Md.
Massachusetts General Hospital, Boston, Mass.
Pfizer Inc. (NYSE:PFE), New York, N.Y.