K-Ras in cancer metabolism

Researchers from the Dana-Farber Cancer Institute have identified two glucose metabolism pathways that are activated by the K-Ras oncogene in pancreatic tumors.¹ Based on the findings, it may be possible to target proteins in the pathways to block proliferation of K-Ras-driven cancers.

Tumors typically grow and proliferate by dramatically increasing their rate of glycolysis compared with that in normal cells. Cancers rely on the process, called the Warburg effect, because it supplies energy and intermediates to sustain tumor growth. Thus, blocking glycolysis and potentially other metabolic pathways in tumors could cut off the malignancy's energy and nutrient supply...