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  • Figure: Battle of the bugs

    The Finnish connection Targets & Mechanisms Battle of the bugs In a study in Cell, an international consortium of researchers showed that susceptibility to Type I diabetes was affected by regional differences in …

    Published on 6/16/2016
  • The Finnish connection

    The microbiome link between Finnish children and Type I diabetes

    By comparing microbiomes of Finnish, Russian and Estonian infants, an international consortium has found a molecular link between Type I diabetes and Bacteroides bacteria.

    Published on 6/16/2016
  • Sanofi's post-reconstruction era

    How research head Yong-Jun Liu is capstone to Zerhouni's R&D overhaul at Sanofi

    Immunology guru Yong-Jun Liu has a mandate to build a biology-based R&D engine at Sanofi and help the pharma make up for lost time in immuno-oncology.

    Published on 6/9/2016
  • Table: Academic Angles

    Sanofi's post-reconstruction era Strategy Academic Angles Select academic institutions involved in recent research collaborations with Sanofi (Euronext:SAN; NYSE:SNY). (A) indicates expired or inactive …

    Published on 6/9/2016
  • Table: Preclinical Peek

    Sanofi's post-reconstruction era Strategy Preclinical Peek Although Sanofi (Euronext:SAN; NYSE:SNY) isn't making its complete preclinical pipeline public, the pharma has disclosed several preclinical programs, some…

    Published on 6/9/2016
  • Digital Preclinical

    How Vium is automating data collection to overhaul in vivo research practices

    Vium is using its techie founders' Silicon Valley know-how to overhaul animal research and increase reproducibility in preclinical studies.

    Published on 6/2/2016
  • Dissociating ketamine

    An NMDA receptor-independent ketamine metabolite might bypass the drug's side effects

    The discovery of a ketamine metabolite that alleviates depression without causing psychedelic effects could upend a major hypothesis about the drug's action.

    Published on 5/26/2016
  • Figure: Converting ketamine

    Dissociating ketamine Targets & Mechanisms Converting ketamine Collaborators at NIH and the University of Maryland used the structures of the (R) and (S) enantiomers of ketamine and its hydroxynorketamine (HNK) …

    Published on 5/26/2016
  • Figure: Ketamine mimics

    Dissociating ketamine Targets & Mechanisms Ketamine mimics The anesthetic ketamine is an NMDA receptor antagonist known to have antidepressant activity, but it also causes severe psychedelic side effects. In a …

    Published on 5/26/2016
  • Table: BioCentury Product Profile

    Dissociating ketamine Targets & Mechanisms BioCentury Product Profile BIOCENTURY PRODUCT PROFILE INNOVATION STAGE Product (2R,6R)-hydroxynorketamine Concept A ketamine metabolite that recapitulates the drug's …

    Published on 5/26/2016
  • Box: Set to launch

    Mind the gap Strategy Set to launch The U.K. government's technology strategy board, renamed Innovate U.K., has created a Catapult Programme composed of 11 centers, each focused on accelerating a different …

    Published on 5/19/2016
  • Mind the gap

    U.K. keeps calm and boosts translational science

    The U.K. is boosting biotech with a slew of new investments and initiatives to help universities spin out discoveries rather than primarily license them to pharmas.

    Published on 5/19/2016
  • Modeling with interference

    How marrying CRISPRi with iPS can produce better disease models

    By marrying CRISPRi with iPS cells, a UCSF team has created a scalable, widely applicable form of genetic knockdown for more - and better - models of disease.

    Published on 5/12/2016
  • Box: Knocking out or knocking down

    Modeling with interference Tools & Techniques Knocking out or knocking down CRISPRi's tunable and reversible gene knockdown makes it an ideal tool for modifications in induced pluripotent stem (iPS) cells, but it …

    Published on 5/12/2016
  • Figure: CRISPRi: Technological knockdown

    Modeling with interference Tools & Techniques CRISPRi: Technological knockdown In a new study in Cell Stem Cell, a group of University of California San Francisco researchers described how to use CRISPR …

    Published on 5/12/2016
  • Figure: As easy as 1, 2, 3, 4...

    Cell therapy's yada yada yada Product R&D As easy as 1, 2, 3, 4... Manufacturing of allogeneic and autologous cells involves seven basic steps before a patient can receive them. (1) Apheresis. Blood is drawn from …

    Published on 5/5/2016
  • Cell therapy's yada yada yada

    Challenges and solutions for GMP manufacturing of cell therapies

    Despite the scientific advances of cell therapy, the less glamorous innovations in manufacturing could be the difference-maker for translational and commercial success.

    Published on 5/5/2016
  • Figure: Measuring acceleration

    Virtually biotechs Finance Measuring acceleration Licensing revenue is often considered a key metric for tracking success of technology transfer offices (TTOs). For universities that are adopting the virtual …

    Published on 4/28/2016
  • Virtually biotechs

    Why early stage academic deals are heating up

    While the $20 million Harvard-Merck licensing deal is unlikely to be matched in size any time soon, it might reflect a growing translational savviness in academia.

    Published on 4/28/2016
  • On the road

    Nine challenges FDA wants scientists to solve for NGS-based diagnostics

    FDA has responded to the explosion of interest in next-generation sequencing for precision diagnostics with a roadmap for solving the big regulatory challenges.

    Published on 4/21/2016
  • Figure: Next year in the clinic...

    On the road Tools & Techniques Next year in the clinic... In a Perspective in Science Translational Medicine, FDA outlined nine informatics research areas to advance regulatory evaluation of next-generation …

    Published on 4/21/2016
  • Next stop: Houston

    How JLABS' new site at TMC plays into Houston's hub hopes

    While JLABS' new site at the Texas Medical Center is a welcome investment in the region, Houston is still in the early days of its quest to become the next U.S. biotech hub.

    Published on 4/14/2016
  • Figure: Companies formed

    Next stop: Houston Strategy Companies formed Total number of new biopharma companies formed in multiple regions of the U.S. from 2010 to 2016. Source: BCIQ: BioCentury Online Intelligence

    Published on 4/14/2016
  • Figure: Seed and series A funding

    Next stop: Houston: Figure: Seed and series A funding Next stop: Houston Strategy Seed and series A funding Seed and series A funding amounts for each region from 2010 to 2016. Total values include all disclosed …

    Published on 4/14/2016
  • Figure: Tri-coastal Spread

    Next stop: Houston Strategy Tri-coastal Spread Total National Institutes of Health (NIH) funding for select academic institutions in the San Francisco Bay Area (blue); Boston and Cambridge, Mass. (green); and …

    Published on 4/14/2016

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