Red blood cell transfusions are among the
most commonly performed medical procedures, but the capacity of the transfused
cells to transport oxygen is often reduced because of biochemical changes in
the cells during storage. Now, Case Western Reserve University and Duke University Medical Center researchers have improved oxygen delivery capacity by
re-nitrosylating hemoglobin prior to transfusion.1
Affecting adverse events and efficacy
Stamler said his group is planning a
clinical trial to obtain baseline measurements on how transfusions with stored
RBCs change oxygen delivery and then determine how such changes correlate with
transfusion-related adverse events. He said his group has received a grant from
to carry out the trial. He declined to disclose the grant amount.
K.-J. SciBX 6(27);
doi:10.1038/scibx.2013.673 Published online July 18, 2013
1. Reynolds, J.D. et
al. Proc. Natl. Acad. Sci. USA; published online June 24, 2013;
doi:10.1073/pnas.1306489110 Contact: Jonathan S. Stamler, Case Western
Reserve University, Cleveland, Ohio e-mail: email@example.com
2. Gladwin, M.T. &
Kim-Shapiro, D.B. Curr. Opin. Hematol. 16, 515-523 (2009)
3. Hébert, P.C. &
Fergusson, D.A. JAMA 292, 1610-1612 (2004)
4. Tsai, A.G. et al.
Transfusion 44, 1626-1634 (2004)
5. Sherwood, M.W. &
Rao, S.V. Nat. Rev. Cardiol. 10, 186-187 (2013)
6. Tinmouth, A. et al.
Transfusion 46, 2014-2027 (2006)
7. Murphy, G.J. et al.
Circulation 116, 2544-2552 (2007)
8. Netzer, G. et al.
Chest 132, 1116-1123 (2007)
9. Reynolds, J.D. et
al. Proc. Natl. Acad. Sci. USA 104, 17058-17062 (2007)
10. Malone, D.L. et al.
J. Trauma 54, 898-905 (2003)
11. Hendrickson, J.E. &
Hillyer, C.D. Anesth. Analg. 108, 759-769 (2009)
AND INSTITUTIONS MENTIONED
Case Western Reserve University, Cleveland, Ohio
Duke University Medical Center, Durham, N.C.
Duke University School of Medicine, Durham, N.C.
Emory University School of Medicine, Atlanta, Ga.
National Institutes of Health, Bethesda, Md.
Wake Forest University, Winston-Salem, N.C.