Thursday, October 18, 2012
Targeting endotrophin in breast cancer. Researchers from The University of Texas Southwestern Medical Center published in The Journal of Clinical
Investigation that blocking the extracellular protein endotrophin reduced breast tumor growth and
in the tumor stroma secrete multiple factors that interact with other stromal
cell types as well as tumor cells [a].
paper identified endotrophin, an extracellular cleavage product of collagen VI
(COL6), as a factor that influenced both cancer cells and stromal cells [b].
In cancer cells, endotrophin induced the epithelial-mesenchymal transition,
which led to increased metastases. In the tumor stroma, endotrophin recruited
and activated macrophages and endothelial cells, which in turn promoted tumor
growth through increased angiogenesis [c].