Thursday, September 27, 2012
A Columbia University team has
evidence that pancreatic islet b cells do not die in
mouse models of type 1 diabetes and type 2 diabetes but rather dedifferentiate
into stem cell-like precursors.1 The findings could explain why diabetes
rapidly resolves in obese patients who undergo bariatric surgery and could
argue for developing strategies to turn these dedifferentiated cells back into b cells to restore insulin secretion in diabetic
Are we not
Osherovich, L. SciBX 5(38); doi:10.1038/scibx.2012.995
Published online Sept. 27, 2012
1. Talchai, C. et al.
Cell; published online Sept. 14, 2012; doi:10.1016/j.cell.2012.07.029
Contact: Domenico Accili, Columbia University, New York, N.Y.
2. Ren, H. et al. Cell
149, 1314-1326 (2012)
Columbia University, New York, N.Y.
Harvard Stem Cell Institute, Cambridge, Mass.
Harvard University, Cambridge, Mass.
NGM Biopharmaceuticals Inc., South San Francisco, Calif.