The vasodilatory effects of adenosine A2A receptor
agonists make them useful as cardiac stress agents in imaging but have made it
difficult to exploit these molecules' potent anti-inflammatory effects.1
Researchers in Germany have dissociated the anti-inflammatory effects of
adenosine A2A receptor agonists from their hemodynamic effects and
are determining a specific inflammation-related indication to pursue with the
Inflammatory history lessons
The prodrug strategy could help
overcome a key barrier that has caused some ADORA2A agonists to
flounder in the inflammation setting.
For your inflammation
Lou, K.-J. SciBX 5(34); doi:10.1038/scibx.2012.887
Published online Aug. 30, 2012
1. Haskó, G. et al.
Nat. Rev. Drug Discov. 7, 759-770 (2008)
2. Flögel, U. et al.
Sci. Transl. Med.; published online Aug. 8, 2012;
Contact: Jürgen Schrader, Heinrich Heine University of Duesseldorf,
3. Deaglio, S. et al.
J. Exp. Med. 204, 1257-1265 (2007)
4. Kobie, J.J. et al.
J. Immunol. 177, 6780-6786 (2006)
5. El-Tayeb, A. et al.
J. Med. Chem. 52, 7669-7677 (2009)
AND INSTITUTIONS MENTIONED
Astellas Pharma Inc. (Tokyo:4503), Tokyo, Japan
CBT Development Ltd., Cambridge, U.K.
Ergomed Group, Frankfurt, Germany
Gilead Sciences Inc. (NASDAQ:GILD), Foster City, Calif.
GlaxoSmithKline plc (LSE:GSK; NYSE:GSK), London, U.K.
Heinrich Heine University of Duesseldorf, Duesseldorf, Germany
La Jolla Institute for Allergy & Immunology, La Jolla, Calif.
New York University Langone Medical Center, New York, N.Y.
Pfizer Inc. (NYSE:PFE), New York, N.Y.
Swedish Orphan Biovitrum AB (SSE:SOBI), Stockholm, Sweden
University of Bonn, Bonn, Germany
University of Colorado Denver School of Medicine, Denver, Colo.