Dampening neuroinflammation

A California team has shown that monoacylglycerol lipase, which controls levels of a pain-reducing metabolite in the brain, also regulates neuroinflammation.¹ The researchers have proof of concept that a small molecule inhibitor of the target blocks inflammation and decreases neurodegeneration in a mouse model of Parkinson's disease, and they are now studying the compound in additional neurodegenerative and neurological diseases.

Newco Abide Therapeutics Inc. is exercising an option to license the monoacylglycerol lipase (MAGL) inhibitors...