Thursday, November 17, 2011
A California team has shown that monoacylglycerol
lipase, which controls levels of a pain-reducing metabolite
in the brain, also regulates neuroinflammation.1 The researchers
have proof of concept that a small molecule inhibitor of the target blocks
inflammation and decreases neurodegeneration in a mouse model of Parkinson's
disease, and they are now studying the compound in additional neurodegenerative
and neurological diseases.
J. SciBX 4(45);
Published online Nov. 17, 2011
1. Nomura, D.K. et al. Science; published online Oct. 20, 2011;
Contact: Benjamin F. Cravatt, The Scripps Research Institute, La
Contact: Daniel K. Nomura, University of California, Berkeley,
2. Long, J.Z. et al. Nat. Chem.
Biol. 5, 37-44 (2009)
3. Nomura, D.K. et al. Nat. Chem.
Biol. 4, 373-378 (2008)
AND INSTITUTIONS MENTIONED
Abide Therapeutics Inc., Princeton, N.J.
Merck & Co. Inc. (NYSE:MRK), Whitehouse Station, N.J.
The Scripps Research Institute, La Jolla, Calif.
University of California, Berkeley, Calif.