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  • Go small or go home

    A portable manufacturing unit for single doses of biologics

    An MIT duo has coupled a small scale bioreactor with cellular engineering to produce single-dose biologics, with applications ranging from process development to the battlefield.

    Published on 8/18/2016
  • Twenty-sided therapy

    Capitalizing on the many facets of 20-sided nanoparticles

    A University of Washington team has created 20-sided protein nanoparticles that can be custom fit for vaccines or drug delivery.

    Published on 8/18/2016
  • Figure: Just a little culture

    Go small or go home Tools & Techniques Just a little culture Massachusetts Institute of Technology (MIT) scientists have coupled a state-of-the-art microbioreactor and a genetically engineered yeast strain to …

    Published on 8/18/2016
  • Table: BioCentury Product Profile

    Go small or go home Tools & Techniques BioCentury Product Profile BIOCENTURY PRODUCT PROFILE INNOVATION STAGE Product Cell line optimized for continuous, switchable production of multiple proteins Concept …

    Published on 8/18/2016
  • Figure: Parts and particle

    Twenty-sided therapy Tools & Techniques Parts and particle In a study published in Science, researchers from the University of Washington described 10 computationally designed protein structures that successfully …

    Published on 8/18/2016
  • Table: BioCentury Product Profile

    Twenty-sided therapy Tools & Techniques BioCentury Product Profile BIOCENTURY PRODUCT PROFILE INNOVATION STAGE Product Self-assembling protein nanoparticles Concept Programmable particles comprising …

    Published on 8/18/2016
  • Neutralizing the flu

    How NIH has streamlined the hunt for neutralizing flu antibodies

    With a new NIH finding that most people make neutralizing antibodies to the flu, the question is whether that translates better to an active or passive vaccine.

    Published on 8/11/2016
  • Figure: Grabbing flu by the stem

    Neutralizing the flu Tools & Techniques Grabbing flu by the stem In a study published in Cell, researchers from NIH's National Institute of Allergy and Infectious Diseases (NIAID) described three classes of …

    Published on 8/11/2016
  • Table: BioCentury Product Profile

    Neutralizing the flu Tools & Techniques BioCentury Product Profile BIOCENTURY PRODUCT PROFILE INNOVATION STAGE Product Universal vaccine for influenza A Concept Prophylactic influenza A vaccine targeting a …

    Published on 8/11/2016
  • Figure: Crossing the aisle

    Best of both worlds Tools & Techniques Crossing the aisle Over the past few years, the focus of immuno-oncology R&D has expanded to include a new type of innate immune cell that straddles the innate and adaptive …

    Published on 7/28/2016
  • Figure: Natural death

    Innate harmony Tools & Techniques Natural death NK cell activity is dictated by activating and inhibitory receptors on the cell surface that work together to distinguish tumor cells from healthy cells. NK cell …

    Published on 7/28/2016
  • Table: Natural killer cell therapeutics

    Innate harmony Tools & Techniques Natural killer cell therapeutics Select natural killer (NK) cell therapies and NK cell-directed antibodies in clinical and preclinical development for cancer. There are two primary…

    Published on 7/28/2016
  • Innate harmony

    Why NK cells are the next big thing in immuno-oncology

    NK cells are becoming the new shiny tool in immuno-oncology, filling out company pipelines for their potential as alternatives or partners for CAR T cells.

    Published on 7/28/2016
  • Best of both worlds

    Why NKT cells could help or even upstage CAR T cells

    Baylor researchers are working in the sweet spot between adaptive and innate immunity to use NKT cells in immuno-oncology.

    Published on 7/28/2016
  • A new route for CARs

    Adapting CAR T technology to treat autoimmune diseases

    A UPenn team has adapted CAR T cell technology to target autoimmune cells, and believes the strategy may work as well in autoimmunity as it does in cancer, with fewer liabilities.

    Published on 7/21/2016
  • Cryo-EM a river

    As cryo-EM races forward, companies are partnering to keep up

    A rush of technical improvements are making cryo-EM an attractive choice for structure-based drug design, and companies are collaborating to catch the wave.

    Published on 7/14/2016
  • Box: New resolutions

    Cryo-EM a river Tools & Techniques New resolutions Fueled by technological improvements in cryo-electron microscopy (cryo-EM), a team at the National Cancer Institute (NCI) has been pushing the method's limitations…

    Published on 7/14/2016
  • Figure: Frozen in time

    Cryo-EM a river Tools & Techniques Frozen in time Researchers at the National Cancer Institute (NCI) have generated a composite image that illustrates how cryo-electron microscopy (cryo-EM) resolution has improved …

    Published on 7/14/2016
  • Figure: No entry

    Home is in the placenta Tools & Techniques No entry In a recent paper in Science Advances, a University of Manchester group found that a pair of tumor-targeting peptides can home to the placenta, without reaching …

    Published on 6/23/2016
  • Table: Preeclampsia pipeline

    Home is in the placenta Tools & Techniques Preeclampsia pipeline Select products in clinical and preclinical development to treat preeclampsia. At least five companies are developing therapeutics for preeclampsia, …

    Published on 6/23/2016
  • Home is in the placenta

    How tumor-targeting peptides could de-risk drug development in pregnancy

    The discovery of placenta-homing peptides that don't reach the fetus could shift the risk-reward ratio for drug development in pregnancy.

    Published on 6/23/2016
  • What GWAS will be

    Two studies help find which GWAS hits actually matter

    With a new way to identify the few functional genetic variants from thousands of hits, two groups have taken GWAS to the next level.

    Published on 6/23/2016
  • Figure: Massive screen of small changes

    What GWAS will be Tools & Techniques Massive screen of small changes Two groups from the Broad Institute of MIT and Harvard have published a pair of studies in Cell showing a massively parallel reporter assay (MPRA…

    Published on 6/23/2016
  • Figure: Massive screen of small changes

    What GWAS will be Tools & Techniques Massive screen of small changes Two groups from the Broad Institute of MIT and Harvard have published a pair of studies in Cell showing a massively parallel reporter assay (MPRA…

    Published on 6/23/2016
  • Figure: Massive screen of small changes

    What GWAS will be Tools & Techniques Massive screen of small changes Two groups from the Broad Institute of MIT and Harvard have published a pair of studies in Cell showing a massively parallel reporter assay (MPRA…

    Published on 6/23/2016

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