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Chronological Index of : Therapeutics

 Current Issue
  • Therapeutics: Cathelicidin antimicrobial peptide (CAMP; CRAMP; LL37)

    INDICATION: Diabetes Mouse studies suggest CAMP could help treat Type I diabetes. In a mouse model of autoimmune diabetes, CAMP levels were decreased in β cells of female mice compared with non-diabetic female mice. …

    Published on 8/27/2015
  • Therapeutics: CTLA-4 (CD152); LPS-responsive vesicle trafficking beach and anchor containing (LRBA)

    INDICATION: Autoimmune disease In vitro and patient sample studies suggest inhibitors of lysosomal degradation could help treat patients with autoimmune diseases caused by LRBA deficiency. Positive responses of LRBA-…

    Published on 8/27/2015
  • Therapeutics: Cyclooxygenase-2 (COX-2); 5-lipoxygenase (ALOX5; 5-LO)

    INDICATION: Inflammation; pain In vitro and mouse studies suggest an inhibitor of COX-2 and ALOX5 could treat pain and inflammation. Chemical synthesis of barbituric acid analogs followed by testing in COX-2 and …

    Published on 8/27/2015
  • Therapeutics: Factor VIII; CRISPR-associated protein 9 (Cas9)

    INDICATION: Hemophilia In vitro and mouse studies suggest gene-edited pluripotent stem (iPS) cells could help treat hemophilia A by restoring Factor VIII expression. In iPS cells derived from two hemophilia patients …

    Published on 8/27/2015
  • Therapeutics: Ferritin heavy polypeptide 1 (FTH1); interleukin-1 (IL-1) β

    INDICATION: Neurology Studies in cells and rats suggest inhibiting FTH1 or IL-1β could help treat HIV-associated neurocognitive disorders. FTH1 levels were higher and dendritic spine density was lower in the brains …

    Published on 8/27/2015
  • Therapeutics: FYN proto-oncogene src family tyrosine kinase (FYN); protein kinase C (PKC) δ (PRKCD)

    INDICATION: Neurology In vitro and mouse studies suggest inhibiting FYN or PKCδ could help treat neuroinflammatory diseases such as Parkinson's disease (PD). In mouse microglia, lipopolysaccharide (LPS)-induced …

    Published on 8/27/2015
  • Therapeutics: G protein α inhibiting activity polypeptide 2 (GNAI2)

    INDICATION: Thrombocytopenia Mouse studies suggest inhibiting GNAI2 or other neutrophil extravasation factors could help prevent hemorrhage in thrombocytopenia patients. In a mouse model of thrombocytopenia, antibody…

    Published on 8/27/2015
  • Therapeutics: Influenza A virus hemagglutinin

    INDICATION: Influenza virus In vitro and mouse studies identified an antibody against influenza A virus hemagglutinin that could help treat influenza. An antibody isolated from peripheral blood mononuclear cells of …

    Published on 8/27/2015
  • Therapeutics: Not applicable

    INDICATION: Liver transplant Mouse studies suggest transplantation of hepatic progenitor cells could promote liver regeneration. Hepatic progenitor cells isolated from a mouse model of hepatocellular injury survived …

    Published on 8/27/2015
  • Therapeutics: Phospholipase D1 (PLD1)

    INDICATION: Colorectal cancer Mouse and patient sample studies suggest inhibiting PLD1 could help treat colorectal cancer. In colorectal cancer patients, levels of PLD1 mRNA were higher in tumors than in surrounding …

    Published on 8/27/2015
  • Therapeutics: Prion protein (PRNP; PrP; CD230)

    INDICATION: Encephalopathy In vitro and mouse studies suggest analogs of the imaging agent luminescent conjugated polythiophene (LCP) could help treat PRNP-mediated spongiform encephalopathy and other diseases …

    Published on 8/27/2015
  • Therapeutics: Protein peptidylprolyl cis/trans isomerase NIMA-interacting 1 (PIN1)

    INDICATION: Cancer In vitro studies identified a cell-permeable peptide inhibitor of PIN1 that could help treat cancer. Screening of a library of analogs of a PIN1-inhibiting peptide in a cell-free PIN1-binding assay…

    Published on 8/27/2015
  • Therapeutics: Syndecan 4 (SDC4)

    INDICATION: Asthma Mouse studies suggest inhibiting SDC4 could help treat asthma. In a mouse model of ovalbumin-induced asthma, SDC4 knockout, or treatment before or after asthma onset with an antibody that inhibits …

    Published on 8/27/2015
  • Therapeutics: Target of EGR1 member 1 (TOE1)

    INDICATION: HIV / AIDS Cell culture studies suggest TOE1 could help treat HIV. In a human cell-based assay of HIV transcription activity, TOE1 decreased transcriptional activation compared with no treatment. In human…

    Published on 8/27/2015
  • Therapeutics: An undetermined target

    INDICATION: Bacterial infection In vitro and mouse studies identified four docosapentaenoic acid (DPA) analogs that could help treat bacterial infections. Liquid chromatography/tandem mass spectrometric analysis of …

    Published on 8/20/2015
  • Therapeutics: Atonal homolog 1 (ATOH1; HATH1); β-catenin (CTNNB1)

    INDICATION: Hearing loss Mouse studies suggest expressing ATOH1 and CTNNB1 in ear hair cell progenitors could help treat hearing loss. In postnatal mice, induced expression of ATOH1 and a constitutively active form …

    Published on 8/20/2015
  • Therapeutics: CD52; T cell receptor (TCR)

    INDICATION: Lymphoma Mouse studies suggest chimeric antigen receptor (CAR) T cells that lack CD52 and endogenous TCR could treat lymphoma. Endogenous TCR on CAR T cell therapies reduces cell survival in vivo and can …

    Published on 8/20/2015
  • Therapeutics: CD68 (LAMP4)

    INDICATION: Malaria In vitro and mouse studies suggest inhibiting CD68 could help treat malaria. Screening of a phage display peptide library for binding to Kupffer cells identified a cell-binding peptide that …

    Published on 8/20/2015
  • Therapeutics: Coronavirus S protein

    INDICATION: Coronavirus Animal studies suggest sequential immunization with DNA vaccine and a subunit of coronavirus S protein could help prevent Middle East respiratory syndrome coronavirus (MERS-CoV) infection. In …

    Published on 8/20/2015
  • Therapeutics: JAK kinase (JAK)

    INDICATION: Dermatitis In vitro and mouse studies suggest JAK inhibitors could help treat dermatitis. In lipopolysaccharide (LPS)-stimulated mouse bone marrow-derived dendritic cells (DCs), the JAK inhibitors …

    Published on 8/20/2015
  • Therapeutics: MicroRNA-196a (miR-196a); v-myc myelocytomatosis viral oncogene homolog (MYC; c-Myc); homeobox B7 (HOXB7)

    INDICATION: Breast cancer Studies in patient samples, cell culture and mice suggest miR-196a or inhibition of MYC could help treat tamoxifen-resistant breast cancer. In tumors from estrogen receptor-positive breast …

    Published on 8/20/2015
  • Therapeutics: Mycobacterium tuberculosis cytochrome bc1

    INDICATION: Tuberculosis In vitro and mouse studies suggest lansoprazole analogs could help treat TB. Screening of a library of FDA-approved drugs in a human cell-based assay of M. tuberculosis infection identified …

    Published on 8/20/2015
  • Therapeutics: Phosphoinositide 3-kinase (PI3K) γ

    INDICATION: Shock / trauma Rat studies suggest inhibiting PI3Kγ could improve recovery following brain surgery, which can damage normal brain tissue. In rats, front-lobe corticectomy-induced brain injury increased …

    Published on 8/20/2015
  • Therapeutics: Protein tyrosine phosphatase 1B (PTP-1B; PTPN1); methyl CpG binding protein 2 (MECP2; RTT)

    INDICATION: Rett syndrome Mouse and patient sample studies suggest inhibiting PTP-1B could help treat Rett syndrome. PTP-1B levels were higher in fibroblasts from Rett syndrome patients than in cells from healthy …

    Published on 8/20/2015
  • Therapeutics: Transglutaminase 2 (TGM2; TG2)

    INDICATION: Cancer; ophthalmic In vitro and mouse studies suggest enhancing TGM2 levels could help treat cancer and ophthalmic diseases by inhibiting angiogenesis. In a human umbilical vein endothelial cell line, an …

    Published on 8/20/2015

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