Skip to main content
BC Innovations
Feature Story

Bad actin

Targeting actin and tubulin in cancer could improve response rates

By Stephen Parmley, Senior Writer

While many companies are looking beyond cytoskeletal inhibitors because of their high off-target toxicity, Novogen Ltd. has teased out a difference between normal and cancer cells in the way actin is regulated by tropomyosins. By targeting the tropomyosin Tpm3.1, the company has produced a first-in-class inhibitor of actin that destabilizes filaments and inhibits growth of neuroblastoma cells without causing widespread toxicity.

Last month, Novogen presented data at the meeting of the Cancer Molecular Therapeutics Research Association (CMTRA) showing its lead Tpm3.1 inhibitor Anisina can also synergize with microtubule inhibitors, and could improve the efficacy and response rates of standard-of-care anti-tubulin drugs. In July, Anisina received Orphan Drug designation from FDA for neuroblastoma. The compound is scheduled to enter Phase I trials in 2016.

Read Article

Today's Biotech & Pharma News

  • THE DISTILLERY brings you this week's most essential scientific findings in therapeutics, distilled by Innovations editors from a weekly review of more than 400 papers in 41 of the highest-impact journals in the fields of biotechnology, the life sciences and chemistry. The Distillery goes beyond the abstracts to explain the commercial relevance of featured research, including licensing status and companies working in the field, where applicable.

    This week in therapeutics includes important research findings on targets and compounds, grouped first by disease class and then alphabetically by indication.

    This week in techniques includes findings about research tools, disease models and manufacturing processes that have the potential to enable or improve all stages of drug discovery and development.

Subscribe Now
Free Trial

Management Updates

There were no items published for this section in the most recent issue. Click more >> to read previously published items.