BioCentury
ARTICLE | Clinical News

Stanford team reports live imaging of CAR T cells

January 20, 2017 1:36 AM UTC

In a paper published online by Science Translational Medicine on Wednesday, researchers reported the first PET-based imaging of chimeric antigen receptor T cells in a cohort of seven glioma patients in a clinical trial. Stanford University radiology professor Sanjiv Gambhir led the work in collaboration with researchers from Sangamo BioSciences Inc. (NASDAQ:SGMO) and the City of Hope (Duarte, Calif.).

The PET-based technology may provide an early glimpse of response to CAR T treatment weeks to months before clinical readouts are available through conventional imaging. The technology lets clinicians follow and quantify T cells homing to tumor sites and can be used to track the cellular therapy longitudinally...