Monday, November 12, 2001
There is a growing body of epidemiological evidence that non-steroidal
anti-inflammatory drugs lower the risk of Alzheimer's disease. A paper in last week's Nature
supports those data, but also concludes that while existing NSAIDs may lower risk, the
doses required for therapeutic use were too high to provide a satisfactory safety and
In addition, the mechanism by which NSAIDs work in AD remains a
mystery. It now appears that while the anti-inflammatory properties of NSAIDs may play a
role, the primary effect is through processing of amyloid plaque precursors.