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A target for Huntington's disease
Monday, October 22, 2001
The molecular basis for Huntington's disease (HD) is known to be
associated with a polyglutamine repeat at the N-terminus of the huntingtin protein (Htt),
which causes formation of protein aggregates in the brain and neurotoxicity. But
researchers have not known how to prevent the aggregates from forming. Last week
researchers published a link between an epigenetic enzyme target and Htt-associated
neurotoxicity that could provide a target to prevent or treat the signs of the disease.
Researchers from the University of California at Irvine and colleagues
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