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REVS: Double-barreled gene targeting
Tuesday, September 4, 2001
One of the problems with gene therapy has been achieving efficient,
cell-specific delivery of genes. Researchers from the University of Alabama at Birmingham
and colleagues last week described a combination of transductional and transcriptional
targeting using adenoviral vectors that they said resulted in a synergistic 300,000-fold
improvement in the selectivity of transgene expression for the lung versus the usual site
of vector sequestration in the liver.
Such a combination approach should have relevance for the design of
other gene delivery systems.
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