One of the problems with gene therapy has been achieving efficient, cell-specific delivery of genes. Researchers from the University of Alabama at Birmingham and colleagues last week described a combination of transductional and transcriptional targeting using adenoviral vectors that they said resulted in a synergistic 300,000-fold improvement in the selectivity of transgene expression for the lung versus the usual site of vector sequestration in the liver.

Such a combination approach should have relevance for the design of other gene delivery systems.