Monday, June 4, 2001
The emergence of mutated HIV strains that are resistant to marketed
non-nucleotide reverse transcriptase inhibitors (nNTRs) or protease inhibitors has
stimulated researchers to look for alternate methods of fighting the virus. Virxsys Corp.
is turning HIV against itself, using a disabled virus as a vector to treat HIV/AIDS
patients. Importantly, it should be hard for viral mutations to render the SmartVector
SmartVector is a gutted HIV, which has been stripped of all sequences
that code for viral proteins; instead, it codes for antisense RNA against the HIV