The emergence of mutated HIV strains that are resistant to marketed non-nucleotide reverse transcriptase inhibitors (nNTRs) or protease inhibitors has stimulated researchers to look for alternate methods of fighting the virus. Virxsys Corp. is turning HIV against itself, using a disabled virus as a vector to treat HIV/AIDS patients. Importantly, it should be hard for viral mutations to render the SmartVector ineffective.

SmartVector is a gutted HIV, which has been stripped of all sequences that code for viral proteins; instead, it codes for antisense RNA against the HIV