Monday, April 9, 2001
The peroxisome proliferator-activated receptors (PPAR) have been
extremely successful as drug targets, with numerous marketed drugs targeting the alpha and
gamma PPARs. Now, work by researchers at GlaxoSmithKline plc (GSK, London, U.K.) suggests
that the function of a third member of the family, PPAR delta, is adaptation to changes in
the lipid content of the diet.
PPARs are members of the nuclear hormone receptor superfamily that are
important for storing and breaking down fatty acids. Three PPAR subtypes (alpha, gamma and