ADME properties are particularly important for antibiotics because the drugs must not only reach the circulation, but must reach and penetrate the specific area of infection at high enough concentrations to maintain efficacy.

Cubist Pharmaceuticals Inc.'s choices of initial development indications for its injectable Cidecin daptomycin - complicated skin and soft tissue infections, and community acquired pneumonia - have provided it with an uncomplicated look at the efficacy of daptomycin without confounding tissue distribution issues because soft tissue and respiratory tract tissues are well vascularized. Thus if a drug reaches the circulation, it can reach those tissues.