Monday, March 26, 2001
Of the many changes in the brain correlated with Alzheimer's disease
(AD), one is an elevation in the neuropeptide galanin. Now a transgenic mouse has been
produced that has elevated galanin levels and displays subtle cognitive deficits
characteristic of AD. The mouse will be useful for investigating galanin receptor
antagonists to treat the disease.
In AD the amount of most neurotransmitters decreases as degeneration
occurs, but galanin is an exception - levels