Burning fat first

Many obesity medications either suppress a person's appetite or block the absorption of dietary fats. An alternative strategy might be to coax the body to burn stored fat as fuel instead of sugar, which muscles use preferentially to fat under normal conditions.

Scientists at the Whitehead Institute and Genset S.A. have determined that a piece of Acrp30, a hormone secreted by fat cells, causes muscles to use free fatty acids from the bloodstream when administered to obese mice.